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WHAT IS DIHYDROCODEINE?
Dihydrocodeine is an opioid pain reliever that is used to treat moderate to severe pain. This medication is chemically related to codeine phosphate and can be combined with aspirin, paracetamol or ibuprofen to enhance its effects. Dihydrocodeine 30 mg is effective in the treatment of acute pain which happens abruptly and is caused by something specific like surgery or a broken bone. It can also be used to treat chronic, or long-lasting, pain conditions like arthritis, fibromyalgia and back pain. tko carts
HOW TO TAKE DIHYDROCODEINE
Dihydrocodeine tablets should be swallowed whole with some water. You can take this medication with or without food and it can be taken as needed or at regular times each day. If you take this medication regularly to treat pain associated with a long-term condition like fibromyalgia, treatment should not end abruptly. Instead, the dose should be reduced gradually to prevent any unpleasant withdrawal symptoms. dab carts
BENEFITS OF DIHYDROCODEINE
This medication is beneficial for the relief of moderate to severe pain. A pain rating scale is often used to measure the intensity of pain. With this numeric scale, scores range from 0 to 10 points with higher scores indicating a more severe level of pain. Dihydrocodeine can treat pain intensity that ranges from a level of 5 to 10 which can be described as follows:
- 5 (distressing pain) – this is constant and deep pain such as a sprained ankle. This type of pain is always noticeable and it interferes with daily activities.
- 6 (very distressing pain) – this is also a deep type of pain such as a tension headache that can dominate your thoughts and interfere with daily functioning.
- 7 (intense pain) – this type of pain prevents a patient from being able to function properly such as a migraine headache.
- 8 (very intense pain) – this type of pain can lead to psychological issues like anxiety and depression, particularly if it becomes a long-term condition.
- 9 (excruciating pain) – this type of pain is extremely intense and demands some form of treatment.
- 10 (unbearable pain) – this is the worst possible pain that can prevent you from being able to enjoy any activity.
On a positive note, dihydrocodeine can be used to effectively relieve moderate to severe pain. This medication stops pain signals from travelling through the central nervous system (CNS), from nerves to the brain. It achieves this effect by binding to opioid receptors and this reduces the amount of pain that you feel. This means that even though the source of the pain may still be present, you will feel less pain. Dihydrocodeine can be used to treat pain due to the following conditions:
- Back pain
- Postoperative pain
Research has shown that up to 80% of the general population experience back pain at some point in their lives. Back pain can be caused by various factors such as prolonged sitting, excessive reaching and lifting heavy objects. Symptoms include a shooting or stabbing pain that can radiate down the leg, a dull ache in the lower back and reduced range of motion. The pain can also vary in terms of severity from being a constant but bearable pain to a sudden, excruciating pain. If you suffer from back pain, you can buy dihydrocodeine online for safe, effective relief. 10mm 1000 round case
Dihydrocodeine can also be used to treat pain associated with fibromyalgia. While the cause of this condition is not fully understood, it is considered to be the result of a problem with how the CNS processes nerve signals. It causes widespread pain all over the body and symptoms can begin after certain circumstances like physical trauma, surgery or stress. Historically, women are more likely to have this condition than men. There is no cure for fibromyalgia but effective medication like dihydrocodeine, along with lifestyle changes like exercise and relaxation techniques, can help control the condition.
Dihydrocodeine tablets can also be used to treat arthritis which is a condition that causes pain, swelling and stiffness in one or more joints. The most common type of arthritis is osteoarthritis which affects the smooth cartilage that lines the joints. This makes movement difficult, leading to considerable discomfort. Pain associated with this condition can be mild to severe and it can get worse over the course of time. Arthritis can restrict daily activities like walking or climbing stairs so it is important to find effective treatment. Dihydrocodeine, physical therapy and self-care can help reduce pain and manage arthritis. buy mephedrone online
Migraine headaches can cause severe, throbbing pain that can be rated as at least 5 on the scale of 1 to 10. This type of headache is usually felt only on one side of the head, however, about 30% of migraines affect both sides. Migraine attacks are often accompanied by disabling symptoms such as nausea, visual disturbances and extreme sensitivity to light and sound. Attacks last between 4 and 72 hours – and depression, anxiety and sleeping difficulties are common among patients who suffer with chronic migraine. Dihydrocodeine 30mg works best when taken at the first sign of an approaching migraine. ghb for sale
Healthcare experts often recommend dihydrocodeine for the treatment of postoperative pain. Managing acute pain after surgery is important because if it is not treated properly, it can become chronic pain. Research has shown that patients who receive effective pain relief after surgery tend to recover quicker and function better several months after surgery. You can now easily order dihydrocodeine online to effectively treat postoperative pain. This medication triggers the release of dopamine which reduces your perception of pain. It slows down the rate of nerve signal transmission which, in turn, prevents pain signals from reaching the brain.
Approved indication for dihydrocodeine is the management of moderate to moderately severe pain as well as coughing and shortness of breath. As is the case with other drugs in this group, the antitussive dose tends to be less than the analgesic dose, and dihydrocodeine is a powerful cough suppressant like all other members of the immediate codeine family (see below) and their cousins hydrocodone, oxycodone and ethyl morphine (a.k.a. dionine and codethyline)
For use against pain, dihydrocodeine is usually formulated as tablets or capsules containing a quarter grain (15 or 16 mg) or a half grain (30 or 32 mg) with or without other active ingredients such as aspirin, paracetamol, ibuprofen, or others. The usual dose is one tablet taken every 4-6 hours when necessary.
Controlled-release dihydrocodeine is available for both pain and coughing as indicated below as waxy tablets containing 60 to 120 mg of the drug, and some formulations intended for use against coughing and the like have other active ingredients such as antihistamines, decongestants and others. Generally, the starting dose would be 60 mg every 12 hours. buy dmt carts
Other oral formulations such as packets of effervescent powder, sublingual drops, elixirs and the like are also available in many places.
Injectable dihydrocodeine is most often given as a deep subcutaneous shot.
The above doses are typical starting doses for “opioid naïve” patients. Existing tolerance to opioids and more severe pain (up to about 6 or 7 on a 1 to 10 scale perhaps) call for higher doses; dihydrocodeine may be more like hydrocodone and oxycodone than codeine and ethylmorphine in lacking a theoretical analgesic ceiling, but toxicity of other ingredients (especially aspirin and paracetamol) and/or the side effects of the opioid itself — especially vasodilation, itching, and other effects of the large quantities of histamine released in the body — generally supervene and thus limit dihydrocodeine to the middle range of painkillers, viz. between ethylmorphine and nicocodeine on the continuum. Controlled-release dihydrocodeine is often taken every 8 hours and even 6 especially when titrating the dose in chronic pain cases and similar situations. Different authorities list the maximum daily dose for dihydrocodeine as being anywhere from 240 mg to 720 mg, all other things being equal.
Dihydrocodeine products which can be purchased over the counter in many European and Pacific Rim countries generally contain from 2 to 20 mg of dihydrocodeine per dosing unit combined with one or more other active ingredients such as paracetamol, aspirin, ibuprofen, antihistamines, decongestants, vitamins, medicinal herb preparations and other such ingredients. In a subset of these countries and foreign possessions, 30 mg tablets and 60 mg controlled-release tablets are available over the counter and chemists may very well be able to dispense the 90 and 120 mg strengths at their discretion. moon rock carts
In the United States, the most common analgesic brands with DHC are: DHC Plus (16 and 32 mg), Panlor SS (32 mg), ZerLor (32 mg), Panlor DC (16 mg) and Synalgos DC (16 mg). These combination products also include paracetamol (acetaminophen) and caffeine. Aspirin is used in the case of Synalgos DC.
The Panlor series is manufactured by Pan-American Laboratories of Covington, Louisiana, and they also market several dihydrocodeine-based prescription cough syrups in the United States.
Dihydrocodeine is sometimes marketed in combination preparations with paracetamol as co-dydramol (BAN) to provide greater pain relief than either agent used singly (q.v. drug synergy).
In the UK and other countries, 30-mg tablets containing only dihydrocodeine as the active ingredient (DF-118) are available.
The original dihydrocodeine product, Paracodin, is an elixir of dihydrocodeine hydroiodide also available as a Tussionex-style suspension in many European countries.
In many European countries and elsewhere in the world, the most commonly-found dihydrocodeine preparations are extended-release tablets made by encasing granules of the ingredient mixture, almost always using the bitartrate salt of dihydrocodeine, of four different sizes in a wax-based binder. The usual strengths are 60, 90, and 120 mg. These tablets are used in some countries, such as Austria, as an alternative to methadone (MS-Contin/MST-Continus type medications and buprenorphine are also used for this purpose) for management of opiate addiction. Common trade names for the extended-release tablets are Didor Continus, Codidol, Codi-Contin, Dicodin (made in France and the major product containing the tartrate salt) and DHC Continus.
Dihydrocodeine is available in Japan as tablets which contain 2½ mg of dihydrocodeine phosphate and caffeine, the decongestant d,l-methylephedrine HCl, and the antihistamine chlorpheniramine, and packets of granules which effervesce like Alka-Seltzer® with 10 mg of dihydrocodeine with lysozyme and chlorpheniramine, marketed for OTC sale as SS Bron. These two formulations may have once contained phenyltoloxamine citrate as the antihistamine component. The manufacturer of SS Bron, IsuIsu, also markets an ibuprofen with dihydrocodeine product called S.Tac EVE. Elsewhere in the Pacific Rim and elsewhere, Dicogesic in analogous to Glaxo/Smith-Kline’s DF-118.
Dihydrocodeine is also the original member and chemical base of a number of similar semi-synthetic opiates such as acetyldihydrocodeine, dihydrocodeine enol acetate, dihydroisocodeine, nicocodeine, nicodicodeine, and the bacon.
As with other opioids, tolerance and physical and psychological dependence develop with repeated dihydrocodeine use. All opioids can impair the mental and/or physical abilities required for the performance of potentially hazardous tasks such as driving or operating machinery if taken in large doses, but have the opposite effect in moderate doses. exotic dab carts
Itching and flushing and other effects of blood vessel dialation are also common side effects, due to histamine release in response to the drug using one or more types of receptors in the CNS and/or other responses elsewhere in the body. First-generation antihistamines such as tripelennamine (Pyrabenzamine), clemastine (Tavist), hydroxyzine (Atarax), diphenhydramine (Benadryl), cyproheptadine (Periactin), brompheniramine (Dimetapp), chlorphenamine (Chlor-Trimeton), doxylamine (NyQuil) and phenyltoloxamine (Percogesic Original Formula) not only combat the histamine-driven side effects, but are analgesic-sparing (potentiating) in various degrees. The antihistamine promethazine (Phenergan) may also have a positive effect on hepatic metabolism of dihydrocodeine as it does with codeine. Higher doses of promethazine may interfere with most other opioids with the exception of the pethidine family (Demerol and the like) by this and/or other unknown mechanisms.
Other side effects include giddiness and a sense of hyperactivity. Many patients and experts have pointed out that many opiates have the effect of generating empathy and improving interpersonal skills in a manner analogous to, but subjectively different from, MDMA, MDA, and many related amphetamine-variant entheogen/empathogen/hallucinogenics. Dihydrocodeine and hydrocodone seem to have this effect somewhat in excess of their theoretical analgesic potency as compared to other opioids. cali carts
As with all drugs, side effects depend on the person taking the medication. They can range in severity from mild to extreme, from headaches to difficulty breathing.
Constipation is the one side-effect of dihydrocodeine and almost all opioids which is near-universal. It results from the slowing of peristalsis in the gut and is a reason why dihydrocodeine, ethylmorphine, codeine, opium preparations, and morphine are used to stop diarrhoea and combat Irritable Bowel Syndrome (IBS) in its diarrhoeal and cyclical forms as well as other conditions causing hypermotility and/or intestinal cramping. The gut itself contains its own opioid receptors, which also allows opioids which do not enter the CNS at all or in appreciable quantites following oral administration such as the pethidine-related drugs loperamide, diphenoxylate, and difenoxin to work in the same fashion in a significant percentage of the population. These drugs also have direct anticholinergic effects which contribute to their action. The loperamide-like drugs, however, can exacerbate cyclical IBS and have little or no effect on the cramps associated with all major forms of IBS and exacerbate the constipation-predominant manifestation of this condition. As a result, the most effective opioids for this spectrum of GI complaints would be whole-opium preparations such as paregoric, laudanum, Dover’s Powder, granulated opium, opium in pill form etc., with codeine and dihydrocodeine working very well also, especially on diarrhoeal and cyclical IBS. Whole opium contains not only morphine and codeine and other narcotic alkaloids but also the alkaloid papaverine, a smooth-muscle relaxant, and other alkaloids, oils, resins and waxes which can help with cramping and other symptoms. Preparations containing both paregoric and extract of belladonna were once available that were probably the strongest and most efficaceous of GI drugs. buy rikodeine
In Hong Kong, Dihydrocodeine is regulated under Schedule 1 of Hong Kong’s Chapter 134 Dangerous Drugs Ordinance. It can only be used legally by health professionals and for university research purporses. The substance can be given by pharmacists under a prescription. Anyone who supply the substance without prescription can be fined $10000 (HKD). The penalty for trafficking or manufacturing the substance is a $5,000,000 (HKD) fine and life imprisonment. Possession of the substance for consumption without license from the Department of Health is illegal with a $1,000,000 (HKD) fine and/or 7 years of jail time. buy ketamine online
In the United Kingdom dihydrocodeine is a Class B drug; however, it is available over-the-counter in small amounts (less than 8 mg), when combined with paracetamol (see co-dydramol). Illegal possession of dihydrocodeine can result in up to 5 years in prison and/or an unlimited fine.
In the USA, it is a DEA Schedule II substance, although preparations containing small amounts of dihydrocodeine are classified as Schedule III or Schedule V, depending on the concentration of dihydrocodeine relative to other active constituents, such as paracetamol (acetaminophen). This scheduling is similar to codeine’s. The DEA’s Drug Code for dihydrocodeine free base and all salts is 9120.
International treaties and the controlled-substances laws of most countries, such as the German Betäubungsmittelgesetz, regulate dihydrocodeine at the same level as codeine. Dihydrocodeine-based pharmaceuticals are especially used where chronic pain patients are able to have essentially OTC access to them provided they are registered with the provincial or national government as such a patient.
Controlled-release dihydrocodeine is a non-prescription item in some places, especially the 60 mg strength. A report by the Ivo Šandor Organisation in 2004 listed Andorra, Spain, Gibraltar, and Austria as having varying degrees of access to these and other dihydrocodeine, nicocodeine, and codeine products. epharma
Dihydrocodeine is the parent drug of a series of moderately strong narcotics including hydrocodone, nicocodeine, nicodicodeine, thebacon, acetyl dihydrocodeine and others.
From the point of view of the organic chemist, the removal of the double bond makes the structure much more stable. It is more resistant to metabolic attack (hence a duration of action of 6 hours rather than 4 for codeine). It is also more stable in acidic, high-temperature environments. Whereas converting codeine to morphine is a difficult and unrewarding task, dihydrocodeine can be converted to dihydromorphine with very high yields (over 95%). Dihydromorphine is widely used in Japan. The dihydromorphine can be quantitatively converted to hydromorphone using potassium tert butoxide.
Due to dihydrocodeine providing a relaxing and euphoric high when taken in higher than therapeutic doses it is quite commonly used recreationally. As mentioned above, dihydrocodeine and its related drugs dihydromorphine and hydrocodone have a tendency to create subjective effects similar to those reported with MDMA such as enhanced empathy, euphoria, talkativeness and ability resuspend or dissolve hang-ups and excessive defense mechanisms. Other opioids may also produce similar effects, but compared to their analgesic strength the dihydrocodeine and hydrocodone series stand out as especially strong. khalifa kush for sale
The onset of action of dihydrocodeine and the subsequent effects are often sufficient to satisfy and pleasantly surprise even heroin users; the article “Dihydrocodeine Information” quotes a heroin user as saying “[chewing Codidol extended-release tablets]…it’s just like gear [i.e. heroin]!”
A typical recreational dose amongst those with low tolerance will be between 150mg-240mg, however it should be made clear not to go too high over this dosage as there has been one instance of death with as low as 400mg with a person without any opiate tolerance.
In both clinical and recreational respects, dihydrocodeine shares with hydrocodone the ability to be significantly boosted by the muscle relaxant Carisoprodol (Soma, Sanoma &c). The doses of both should be reduced and those who carelessly take these two drugs at the same time seriously endanger their health. Nonetheless, this kind of mixture has a legitimate place in medicine and can he very helpful if undertaken properly: some proprietary Carisprodol preparations and doctors’ orders for prescription compounding are mixtures of that drug with an NSAID, other ingredients like caffeine, dextromethorphan, vitamin C, cimetidine, paracetamol, antacids, antihistamines, all on top of a weak to moderately weak opioid such as codeine or dihydrocodeine. A common example is the three strengths of Soma Compound With Codeine No. 1, 2 or 3 — i.e. with 8, 16 and 32 mg of codeine phosphate.